Department of Anatomical and Molecular Pathology, University of Coimbra, Portugal
Original Research Article
Vimentin and Ki-67 Acting as Immunotherapy Predictive Biomarkers in Pulmonary Carcinomas Transthoracic and Bronchial Biopsies
Author(s): Maria Ines Figueiredo*, Ana Ladeirinha, Ana Alarcao, Vitor Sousa and Lina Carvalho
Introduction: Programmed death-ligand 1 (PD-L1) expression became a routine biomarker to preview response to
programmed death-1 (PD-1)/PD-L1 inhibitors, with diverging parameters concerning PD-L1 scoring and variable
response to immunotherapy agents. The aim of this study was to evaluate association between PD-L1 expression
and immunohistochemistry panel applied in Pathology practice, defining any of those antibodies as biomarkers
concurrent in patient’s selection for PD-1/PD-L1 blockade therapy.
Methods: A total of 97 cTNM IIIb/IV staged pulmonary carcinoma biopsies were randomly selected between
2018/2020, after adequate representativeness and PD-L1 expression scored through Dako 22C3 antibody. The
panel with cytokeratin 7, thyroid transcription factor 1 (TTF1), cytokeratin 5.6, cluster of differentiation 56 (CD56),
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DOI: 10.36648/iprjo.6.2.5
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