Department of Nutritional Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Japan
Review Article
Regulatory and Pathophysiological Roles of Reactive Oxygen Species in Skeletal Muscle
Author(s): Anayt Ulla and Takeshi Nikawa*
Skeletal muscle is a complex organ in the body that has pivotal roles in movement, respiration, metabolism, and
other normal daily activities. Owing to its contractile activity, oxygen consumption and metabolic functions, oxidant
species, such as Reactive Oxygen Species (ROS) or Reactive Nitrogen Species (RNS) are continuously generated
in skeletal muscle. ROS/RNS have been reported to have dual functionality in skeletal muscle: They may induce
oxidative damage, tissue dysfunction, and myopathy, but they can also regulate various biochemical processes,
such as gene expression, calcium signaling, and contractility to confer beneficial effects on the organism. In skeletal
muscle, the precise action of ROS/RNS has been found to be linked to their concentration. At lower concentrations,
they generally act as regulatory molecules to enhance muscle force and muscle func.. View More»
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