Department of Chemistry, Silpakorn University, Nakorn Pathom, 73140, Thailand
Research Article
Evaluation of Limonene ?-Amino Alcohol Derivatives for Synergistic Antibacterial activity against Staphylococcus aureus
Author(s): Weerachai Phutdhawong, Benjamart Ruangrote, Tongchai Taechowisan and Waya S. Phutdhawong*
Limonene β-amino alcohols were synthesized and evaluated for their antimicrobial activity against Staphylococcus aureus Sp3, the ciprofloxacin resistance stain through the expression of the NorA
efflux pump, and synergistic activity were evaluated by checkerboard and time-kill curves. The results
showed that most of the synthesized compounds were found to exhibit potent activity. Synergistic
investigation of combinations of the synthesized compounds with ciprofloxacin clearly suggested that
compounds 6b and 6h exhibited enhanced synergistic effects (FICI of 0.25) which could provide novel
therapeutic strategies for the treatment S. aureus infection. .. View More»
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