Tbilisi State University, Georgia
Research Article
Biomarkers in Heart Failure with reduced Left ventricular ejection fraction, Prognostic significance
Author(s): Tamar Shengelia*, Bezhan Tsinamdzgvrishvili, Kakha Nadaraia, Liluashvili K, Talakvadze T, Avaliani T, Klimiashvili Z and Rigvava L
Background: Soluble Suppression of Tumorigenicity 2 (sST2) belongs to the interleiukin-1 receptor family and has been found to be elevated in different cardiovascular conditions. However, its utility in predicting the severity of diseases or mortality outcomes has been a topic of debate. This study explores the relationship between soluble ST2 (sST2) and the prognosis of heart failure patients with reduced ejection fraction.
Methods: The study involved measuring sST2 at baseline (N=111), 1 month and 12 months in heart failure patients with reduced EF. Patients with chronic heart failure with enrolled randomly. The analysis employed a non-linear model to assess the association between sST2 and primary outcomes: Cardiovascular mortality, number of hospitalizations with diagnosis of Acute Decompensated Heart Failure (ADHF), and composite rate of d.. View More»