Department of Biochemistry, Karpagam Academy of Higher Education,Coimbatore, Tamil nadu, India
Research Article
Cardio Protective Role of Ageratum conyzoides L. on Cardiac Mitochondrial Enzymes during Isoproterenol Induced Myocardial Infarction in Rats
Author(s): Brindha Elangovan*, Abhirami S Ajayakumar and Ranjani Priya Anandraj
The present study is to evaluate the preventive role of Ageratum conyzoides L. on mitochondrial
enzymes such as is Citrate Dehydrogenase (ICDH), Succinate Dehydrogenase (SDH), Malate
Dehydrogenase (MDH), and α-Ketoglutarate Dehydrogenase (α-KGDH) and respiratory chain enzymes
such as NADH dehydrogenase and cytochrome c oxidase in Isoproterenol (ISO) induced Myocardial
Infarction (MI) in male albino wistar rats. Rats were orally pre treated with Ageratum conyzoides L.
(100 and 200 mg/kg) to ISO induced rats daily for a period of 56 days. After the treatment, rats were
subcutaneously injected with ISO (85 mg/kg) at an interval of 24 hrs for 2 days. ISO induction also
showed a significant (p<0.05) decrease in the activities of enzymes such as ICDH, SDH, MDH, α-KGDH,
NADH dehydrogenase, and cytochrome c oxidase. Pre treatment .. View More»
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