Department of Obstetrics and Gynecology, University of Amsterdam, Amsterdam, The Netherlands
Mini Review
Angiogenesis in Gynaecological Cancers and Anti-angiogenesis Therapy Options
Author(s): Christianne Amant*
Angiogenesis is required for the growth of primary tumours and secondary metastases in cancer, including
gynaecological cancers. The development and improvement of anti-angiogenesis therapy in gynaecological cancers
has been a major focus of fundamental and clinical research. Current anti-angiogenic agents, such as bevacizumab,
have modest survival benefits in patients with gynaecological cancer. As a result, a better understanding of
angiogenesis and the tumour microenvironment in gynaecological cancers is critical for developing more
effective antiangiogenic therapies, whether alone or in combination with other therapeutic approaches. We
discuss the molecular aspects of (tumour) blood vessel formation and the tumour microenvironment, as well
as a comprehensive clinical review of current anti-angiogenic therapies for gynaecological cancers.We discuss
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