Department of Anesthesiology, Cooper University Hospital, Camden, NJ, USA
Mini Review
Impact of Vascular Aging in Patients Presenting with Hypertension, Coronary Artery Disease or Heart Failure and Cardiogenic Shock
Author(s): Lawrence J Mulligan*, Christopher Potestio and Kenyon Sprankle
Cardiogenic Shock (CS) presents a complex physiological environment for physicians to navigate. The presence of CS is frequently found in patients suffering from Hypertension (HTN), Coronary Artery Disease (CAD) and Heart Failure (HF). Adding to these disease states is the underlying and underappreciated state of Vascular Aging (VA) and sub sequent microvascular dysfunction. Vascular aging includes the loss of aortic compliance and is logically associated with the disease states listed and is quantified using pulse-wave velocity and an increase in the Augmentation Index (AIx).
These disease states are also associated with a loss of microvascular regulation of blood flow. The loss of aortic compliance coupled with microvascular dysfunction presents a complicated setting for the intensive care physician. Restoration of perfusion pressure is the goal, but the presence of vascul.. View More»
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