Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Nigeria
Research Article
Drug-Excipient Compatibility: Preformulation Study with New Grades of Microcrystalline Cellulose from Potential Non-Woody Sources, Sorghum and Andropogon
Author(s): Alfa John*, Chwukwu Amara and Udeala O Kelechi
Compatibility of Sorghum and Andropogon Microcrystalline Cellulose (MCC) with acetaminophen, ascorbic acid and metronidazole was examined using FTIR. Tablet characteristics of the binary blends were studied. Drug-excipient ratio was 70:30% w/w for acetaminophen and ascorbic acid while metronidazole was 67:33% w/w. Spectra of the polymer, drug and polymer-drug blends were studied within 400-4000 cm-1 wave number. Characteristic peaks were observed for functional group traits. Tablet batches were obtained for each drug using the derived MCC grades as dry binders, at three different pressure units. Tablets made at fixed pressure units were compared with those of Avicel PH 101. Disintegration, friability, crushing strength and dissolution profiles served as bases for assessment. Peaks of functional groups remained within reference range for the drugs in the drugpolymer blends; .. View More»
DOI: 0.21767/IPIPR.6.6.31
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