Division of Gastroenterology, Department of Medicine, University of California, San Diego, United States
Opinion
Hepatic Glucagon Receptor (GCGR) Signaling to Drive Alpha Cell Hyperproliferation and Pancreatic Neuroendocrine Tumor Formation.
Author(s): Dantas M. Alva*
Hypoglycemia causes the pancreatic alpha cells to produce glucagon, which promotes hepatic glucose synthesis. Deregulated glucagon secretion is linked to type 2 diabetes, and elevated glucagon levels contribute to diabetic hyperglycemia. Endocrine cells of the pancreatic islets are known as alpha cells (α-cells). They make up to 20% of human islet cells, which synthesize and secrete the peptide hormone glucagon, which raises blood glucose levels. .. View More»
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