Department of Biotechnology, University of Management and Technology, Sialkot, Pakistan
Review Article
Apolipoprotein E4 and its Associated Risk to Trigger Alzheimer?s Disease
Author(s): Faiza Nadeem* and Sajid Ali
Background: Alzheimer’s disease is a common type of age related neurodegenerative disorder
characterized by neuronal degeneration and death. The disease can be categorize into three major
types, all which share the same symptoms of progressive cognitive impairment, memory loss, and
behavioral changes, as well as the same brain pathology of neurofibrillary tangles and amyloid plaques.
The age at which each type of Alzheimer’s disease develops is the key factor that distinguishes it from the
others. The APOE genotype is the most significant risk factor for late onset Alzheimer’s disease, as it
encodes an Apo lipoprotein called apolipoprotein E. The E-gene has three different forms or alleles.
The causes of the disease are not fully understood, but both genetics and environmental factors that are
believed to play a role. Despite .. View More»
DOI: 10.36648/IPAD.6.4.31
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