Department of Mental Health, Federal University, Ponta Grossa, Brazil
Case Report
Stages of Mild Cognitive Impairment and Alzheimer?s Disease can be Differentiated by Declines in Timed Up and Go Test: A Systematic Review and Meta-Analysis
Author(s): Felipe de Oliveira Silva*
In Alzheimer's disease, cognition now responds to several drugs. Anti-cholinesterase’s target the
acetylcholine deficit. In mild-to-moderate Alzheimer's disease, they all provide significant benefit
versus placebo on the Alzheimer's Disease Assessment Schedule Cognitive section (ADAS-Cog), side
effects, in 5% to 15% of cases, include nausea, vomiting, diarrhea, anorexia and dizziness. Tacrine, the
leading anti-cholinesterase, caused frequent hepatic enzyme elevation and was withdrawn; once-daily
donepezil spares the liver and improves global measures of change in severe dementia; rivastigmine is
indicated in comorbid vascular disease; at the same time as galaniamine modulates the cerebral
nicotinic acetylcholine receptors that potentiate the reaction to acetylcholine. Alternative agents
encompass the N-Methyl-D-Aspartate (NMDA) receptor antagonist, memani.. View More»