GFC Life Science Co. LTD, Republic of Korea
Research Article
RTN3 (Reticulon 3) as a Novel Prostate Cancer-Specific Biomarker derived from Exosome
Author(s): Ye-Eun Kim, Anh-Thu Nguyen, Jin woo Min, Mi Jung Kim, Ki-Young Kim* and Hee cheol Kang
Objective: Prostate cancer accounts for a large proportion of male cancer deaths worldwide.
Commonly used prostate-specific antigens (PSA) lead to over diagnosis, so novel prostate cancer diagnostic markers are needed. Several substances derived from exosomes affect the progression of cancer. Therefore, it is possible to predict the cancer progression through exosome derived markers.
Design: In order to find a candidate protein that can be used as a biomarker among the exosomal protein coding 7145 genes, screening was performed using qRT-PCR. The genes selected through screening were subjected to western blot to confirm protein expression in cells and protein expression in cancer cell derived exosomes. Afterwards, the function of the corresponding exosomal protein was confirmed through Invasion Assay.
Result:.. View More»
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