Department of Molecular Biology, Dow University of Health Sciences, Pakistan
Mini Review
Role of Cx43 and SLC25A51 Transporters-New Perspectives in NAD+ Supplementation to Improve Mitochondrial Performance
Author(s): Bamboo XZ Yan, WeiGuo Lao, Chi Zhang, Thombas Ebjer and Hina Asrar*
NAD+ , a linchpin for mitochondrial function, is crucial in protecting the body from aging and related diseases. The reduced biosynthesis and increased activity of NAD+ consuming enzymes lower cellular contents of NAD+ with aging. Since the homeostasis of the NAD+ pools is vulnerable to biological aging, and thus, raises a serious concern for the healthcare staff to cure age-related disorders. Replenishing NAD+ pools with the administration of relevant supplements rescues the depleting cellular NAD+. Accordingly, the small-scale human clinical trials have shown ameliorative effects of exogenous NAD+ in treating age-related disorders. However, validation of these studies requires considerable time. Therefore, investigations on a rapid and targeted influx of NAD+ are fundamental to achieving the bene.. View More»
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