Department of Veterinary Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia
Review Article
Overview on Gene Therapy Technology
Author(s): Isayas Asefa Kebede*
Gene therapy is a method of prevention or treatment specifically used to treat patients who are suffering from diseases due to defective genes. It is one part of gene based DNA technology and this therapy became possible through advance of genetics and bioengineering that enable manipulation of vector for delivery of gene. It has some requirements, which should be met such as genes of interest must be cloned; treatment should deliver sufficient copies of normal genes to target cells transferred genes should have stable expression. There are two gene therapy types, germ line and the somatic and are two basic delivery systems: In vivo, which involves direct vector injection into the body; and ex vivo, which involves genetic modification of cells in culture followed by transplantation. Gene cannot be directly inserted into an organism’s cell. It must be delivered .. View More»
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