Department of Chemistry, Fort Hays State University, USA
Research Article
RNA Interference of Three Genes of the Unfolded Protein Response:
Activating Factor of Transcription 4, Eukaryotic Translation Initiation
Factor 2-alpha Kinase, and Inositol-Requiring Enzyme 1 in Acyrthosiphon
pisum
Author(s): Jared Ridder and James Balthazor*
The Activating Transcription Factor 4 (ATF4) is a transcription factor that can act as both an activator and repressor
and is a critical component of the Unfolded Protein Response (UPR) and Amino Acid Response (AAR) pathways.
Inositol-requiring enzyme 1 (IRE1) is an Endoplasmic Reticulum (ER) membrane bound kinase/endoribonuclease
that functions as a sensor of unfolded protein and is the most conserved component of the UPR in eukaryotes.
Eukaryotic Initiation Factor-2-alpha Kinase (PERK) is an ER membrane bound kinase that phosphorylates eukaryotic
initiation factor upon activation of the UPR causing downregulation of protein synthesis. It was hypothesized
that introduction of double stranded RNA (dsRNA) complementary to each of the target genes to aphid diet may
correlate with a change in expression of each gene. The objective of this study was to determine the p.. View More»
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 