Spine Center Division, Department of Teaching, Research and Development, Schulthess Clinic, Zurich, Switzerland
Research Article
The Effect of Depressive Symptoms and Blood Plasma Cortisol on Pain and Quality of Life after Single Segment Lumbar Fusion Surgery
Author(s): David Bellut*, Anne F Mannion, Jan-Karl Burkhardt, Urs Mutter, Francois Porchet and Andre Richter
Objective: Low Back Pain (LBP) is common and surgical treatment for LBP can
fail for many different reasons, one being depressive symptoms and anxiety
contributing to persistent symptoms. We prospectively analyzed Cortisol plasma
levels and depressive symptoms on outcome regarding pain and quality of life
after instrumented fusion.
Methods: Patients (n=50) underwent instrumented fusion for LBP. Before surgery,
patients completed the Beck Depression Inventory (BDI) and the Core Outcome
Measures Index (COMI). Demographic variables and history of depressive
symptoms were noted and blood plasma cortisol measured. Outcome was
evaluated at 3 and 12 months’ follow-up.
Results: There was a significant postoperative improvement in mean COMI total
score and subscores. There was no association bet.. View More»
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