Department of Medicine, St. Luke’s Medical Center, Quezon City, Philippines
Case Report
Case Report: Alveolar Rhabdomyosarcoma of the Prostate Presenting as Lower Urinary Tract Symptoms in a Young Adult
Author(s): Tiffany Grace C. Uy*, Gale Rizzae M. Alcala, Joseph C. Bocobo, Carmella Lou A. Bingcang, Anna Marie M. Pascual-Panganiban, Agnes S. Evangelista-Gorospe, Juliano Zacarias K. Panganiban and Marcelo Severino B. Imasa
Introduction: Rhabdomyosarcoma (RMS) of the prostate in young adults is exceedingly rare.
Case presentation: A 27 year-old male presented with 2-month history of lower urinary tract symptoms. Prostate
was enlarged smooth nontender with no nodularities. PET-CT showed prominent iliac chain lymph nodes, enlarged
spleen and multiple osseous lytic and blastic lesions. Histopathology of prostate tissues revealed round cell malignancy,
positive for Desmin and myogenin. Archer analysis was positive for PAX3: FOXO1 fusion gene. Patient wasdiagnosed
as Alveolar Rhabdomyosarcoma of the prostate Stage IVB (cT4N1M1B-bone). He underwent Vincristine,
Dactinomycin and Cyclophosphamide (VAC) chemotherapy.
Conclusion: Prostatomegaly and splenomegaly are unusual findings in a young male. A high index of suspicion will
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