Department of Cellular and Molecular Biology, CSIR-Indian Institute of Chemical Technology, CSIR, Hyderabad, Telangana, India
Research Article
Absence of WDR13 in p53-Null Mice Increases Longevity
Author(s): Arun Prakash Mishra* and Jyothi B Lakshmi
Absence of WDR13 is known to be involved in pancreatic, colon and uterine hyper proliferation.
However, a recent study showed its anti-proliferative role liver regeneration in response to
hepatotoxins. These findings intrigued to study the role of WDR13-null condition in Trp53 knockout
mouse to study the tumor predisposition and survival. We report absence of Wdr13 in Trp53 null
background alleviates the tumor load, in turn increasing total survival in mouse model. .. View More»
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