Department of Hematology and Immunology, Kanazawa Medical University, Japan
Commentary Article
Castleman Disease, TAFRO Syndrome and Related Disorders
Author(s): Yasufumi Masaki*, Yusuke Ueda, Hiroto Yanagisawa, Tomoyuki Sakai and Kazuyuki Yamada
Castleman B described patients with mediastinal tumors mimicking thymomas with characteristic histopathology, and this condition was named Castleman disease (CD). CD has been classified clinically as Unicentric CD (UCD) and multicentric CD (MCD). Histopathologically, CD has been classified as hyaline vascular type, plasma cell type, mixed type, hyper-vascular type, and plasmablastic type. MCD has been etiologically classified as human herpesvirus- 8-related (HHV-8-related); HHV-8-unrelated, aka idiopathic MCD (iMCD); polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome-related, and others. Furthermore, iMCD has also been classified as iMCD with thrombocytopenia, anasarca, fever, reticulin myelofibrosis or renal insufficiency and organomegaly (TAFRO syndrome), and iMCD not otherwise specified. Thus far, we have discussed diseases that have been nam.. View More»
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 