Journal of Alzheimer's & Dementia Open Access

Department of Veterinary Medicine, University of Camerino, Camerino, Italy

Publications

• Short Communication   
  Orally Administered Probiotics Modulate Gut Microbiota and Restore Glucose Homeostasis in a Mouse Model of Alzheimer?s Disease
  Author(s): Laura Bon Ili*
  
  Cerebral glucose homeostasis deregulation has a role in the pathogenesis and the progression of Alzheimer’s Disease (AD). Current therapiesdelay the decline in cognitive capabilities and reminiscence loss without definitively curing AD. Recent studies have focussed on the role of the gut microbiota in disorders associated with the central nervous system, with special interest in the modulation of the gut-brain axis. Using 3xTg-AD triple transgenic AD mouse model, we have demonstrated that the oral administration of a formulation of lactic acid bacteria and bifidobacteria (namely SLAB51) counteracts cognitive decline, reduces Aβ aggregates and brain damages and partially restores the impaired neuronal proteolysis. Improvement of cognitive function is supported by enriched gut content of antiinflammatory Short Chain Fatty Acids (SCFAs) an.. View More»
  

  DOI: 10.36648/ipad.24.7.13

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