Department of Neurophysiology, University of Belgrade, Serbia
Mini Review
Aluminium Neurotoxicity and Neuroprotection.
Author(s): Ljiljana Martac*, Jelena Podgorac, Branka Petkovic and Gordana Stojadinovic
Aluminium is considered to be the most widely distributed metal in nature and industry and is extensively used in
products and processes associated with human activity. Contamination may occur by air, water, food, additives, medicaments,
vaccines, cosmetics, agrochemicals, etc. Aluminium is recognized as a highly neurotoxic element in animals
and humans connected with several diseases such as Alzheimer’s and Parkinson’s disease, neurodegenerative
motor disorders, encephalopathy, dementia, amyotrophic lateral sclerosis, multiple sclerosis, and autism. There are
many animal models in rats developed to investigate aluminium neurotoxicity. Nevertheless, molecular mechanisms
of its action are not yet resolved, and mechanisms of damage and safety concentrations are still much discussed.
The brain is the most susceptible system to damages provoked by aluminiu.. View More»
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