Icahn School of Medicine at Mount Sinai, New York City, USA
Research Article
E-cigarette/Vaping Associated Lung Injury (EVALI) Severity Correlates with Reduced Diffusing Capacity, Need for Lung Biopsy, and Deposition of Titanium in Lung Tissue
Author(s): Andrew Weber, Vicken Khazar, Samuel Escobar, Robert Promisloff, Keely Cheslack-Postava, Juergen Thieme, Mary Lee-Wong and Anthony M Szema*
Originally marketed as a safer tool for cigarette smoking cessation, electronic cigarettes (e-cigarettes) and vaping
devices have now been associated with e-cigarette/vaping associated lung injury (EVALI). Examination of lung tissue
from these patients is infrequent. We now report a cohort of 19 vaping adults hospitalized with EVALI (IRB 20-
0094 Feinstein Institutes of Medical Research, Northwell Health). 8 patients were biopsied and one patient’s lung
tissue was examined at Brookhaven National Laboratory’s National Synchrotron Light Source II Beam Line ID-5 for
the presence of metals. This sample contained abundant amounts of titanium and small amounts of chromium,
iron, zinc, calcium, and copper. Vaping coils contain titanium, which is heated via a battery and aerosolized in the
inhaled plume. Titanium is pro-inflammatory and may induce lun.. View More»
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