Department of Biotechnology, Kyung Hee University, Republic of Korea
Research Article
STEAP1 as a New Diagnostic Marker Candidate for Prostate Cancer
Author(s): Ye-Eun Kim, Minho Kim, Jin woo Min, Mi Jung Kim, Ki-Young Kim* and Hee cheol Kang
Objective: Prostate cancer is the second most common cancer among men in the world. Although the diagnosis
rate through PSA has increased, PSA also showed false positive even in non-prostate cancer patient. Therefore,
it needs to provide more specific diagnostic markers. STEAP1 is involved in cell to cell communication. It is also
highly expressed specifically in prostate cancer. Therefore, by evaluating the expression level of STEAP1 in exosomes,
we intend to evaluate its potential use as a diagnostic marker.
Design: In order to test the expression level of STEAP1 in the prostate cancer cell line, the gastric cancer cell line
and keratinocyte, RT-PCR was initially used. To check whether STEAP1 is present in the exosome, the protein
expression level was checked using western blot and its role in cell migration was investigate.. View More»
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