Department of Microbiology, Infectious Diseases-Molecular Genetics Division, Mahindra University, Hyderabad, Telangana, India
Research Article
Pathogenesis of SARS-CoV-2 and its Variants
Author(s): Murtaza Bohra, Uma Rani and N Murugan*
COVID-19 is a major health concern globally. The virus found to have zoonotic transmission
with latency period of the virus is 2-14 days. These viruses majorly infect the type 2 pneumocystis
in the alveoli of lungs by binding to the Angiotensin Converting Enzyme 2 (ACE-2) with the help
of spike proteins. The virus divides and replicates using host organism’s replication machinery and get
released into the surrounding cells by exocytosis. In response to the virus, the host body release
inflammatory mediators which results in cytokine storm and leads to high fever and impaired
oxygenation. .. View More»
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