Department of Cancer Molecular Genetics, University of Campinas (UNICAMP), Brazil
Research Article
Investigation of Non-Synonymous Snps in Genes Associated with Oxidative Stress that may be Important in Thyroid Carcinogenesis
Author(s): Teixeira ES, Dal’ Bó IF, Nascimento M, Leão SLS, Ferreira Filho AC, Torres IOS, Rabi LT, Peres KC, Cunha LL, Bufalo NE and Ward LS*
Thyroid cells have intense circulation of free radicals and oxidizing metabolites such as hydrogen peroxide, from the synthesis of thyroid hormones, and iodide, from the iodination of thyroglobulin. Without an efficient antioxidant system, the generation of reactive oxygen species (ROS) can cause deleterious effects leading to DNA damage. ROS have been associated with many diseases, including cancer. Mitochondrial superoxide dismutase MnSOD (SOD2), glutathione peroxidase (GPX-1), glucose-6-phosphate dehydrogenase (G6PD), and p22phox (one of the subunits of the NOX enzyme complex) are transcribed by the SOD2, GPX-1, G6PD and CYBA genes, respectively. They play an important role in the generation of reactive species and in redox control and are crucial in cellular protection against oxidative stress. Genetic variants can affect protein function and therefore promote disturbances of redo.. View More»
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