Division of Biochemistry, Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, Hungary
Perspective
Relation with Glucagon-Like-Peptide-1 Receptor and Extrapancreatic Glucagon
Author(s): Robert Petrika*
The Glucagon-Like Peptide-1 Receptor (GLP1R) is a receptor protein present on pancreatic beta cells as well as brain neurons. It helps to regulate blood sugar levels by increasing insulin secretion. The GLP-1RAs have been found to lower body weight and improve glycemic indices. These drugs function by activating GLP-1 receptors in the pancreas, resulting in increased insulin release and decreased glucagon release-both glucose-dependent responses-and a reduced risk of hypoglycemia. Diabetes is caused by a lack of insulin and an oversupply of glucagon. Extra pancreatic glucagon was identified in dogs, which overturned the prevalent orthodoxy and allowed for detailed examination of the functions of insulin and glucagon in physiology and diabetes, as well as definitive proof about the involvement of glucagon in diabetes. Glucagon was thought to have impacts on many organs prior to his stu.. View More»
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