Department of Pediatrics, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
Mini Review
Early Pregnancy Metabolism and the Development of Systolic Blood Pressure
Author(s): Romy Gaillard*
The development of blood pressure has a significant impact on the aetiology and prognosis of gestational
hypertension diseases. The study of new metabolites that might be used to predict gestational hypertensive
diseases and reveal underlying metabolic pathways in the genesis of hypertension in pregnancy are both possible
outcomes of metabolomics. Liquid chromatography—mass spectrometry was used to measure the blood
concentrations of amino acids, non-esterified fatty acids, phospholipids, and carnitines in early pregnancy in
a population-based, prospective cohort research involving 803 pregnant women. Every trimester of pregnancy
saw blood pressure readings. Medical records were used to gather data on illnesses that cause gestational
hypertension. Throughout pregnancy, increased systolic blood pressure was linked to higher individual metabolite
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