Division of General Internal Medicine, McGill University, Canada
Case Report
Case Report: Giant Cell Arteritis, a Para-Neoplastic Manifestation of Acute Myeloid Leukemia
Author(s): Safaa Azzouz* and Jonathan How
We present a case of a previously healthy 61 year old female with a new diagnosis of Giant Cell Arteritis (GCA),
initially treated with prednisone. One month later, she receives the diagnosis of Acute Myeloid Leukemia for which
she gets a course of 7+3 induction chemotherapy. Clinicians need to be aware that large vessel vasculitis can be the
first sign of a para-neoplastic syndrome related to a hematological malignancy. It has been hypothesized that blood
malignancies such as leukemia are associated with depletion of the T-regulatory cells and overproduction of IL-6 and
TNF-alpha. More research will need to be conducted in order to determine the relationship between GCA and DNA
mutations such as in clonal hematopoiesis of indeterminate potential. .. View More»
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