Department of Respiratory Medicine and Respiratory Oncology, National Institute of TB and Respiratory Diseases, New Delhi, India
Review Article
A Comparison of Combined Cryotherapy and Chemotherapy versus Chemotherapy Alone in Centrally Located Advanced Lung Cancer
Author(s): Salunkhe KA* and Saini JK
Background: Endobronchial cryotherapy is a useful tool in a bronchoscopy suite. This study was
conducted to compare the effects of endobronchial Cryotherapy combined with Chemotherapy (Cr
+CT) in advanced, centrally located lung cancer versus only Chemotherapy (CT) over 18 months.
Materials and methods: Patients with advanced lung cancer were enrolled in two groups: Patients
receiving Cr+CT and patients receiving CT. In the Cr+CT group, 48 hours prior to every chemotherapy
cycle, cryoptherapy was done on the lesion. EORTC Quality of Life (QOL) assessment using LC-13 and
C-30 modules was done at every cycle. RECIST assessment was done at every third cycle of either
therapy.
Results: This study included 30 patients (males-76.6%) with mean age (± Standard Deviation (±
SD))=60.5 (±.. View More»
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