Department of Biochemistry, Laboratory of Biochemistry and Biophysics Instituto Butantan, Brazil
Research Article
Searching for Biomarkers Candidates of Autism Spectrum Disorder with Metabolic Disorders Evidences for a Possible Role of Proteins and Amino Acids Content in Urine
Author(s): Silva NI, Cunha AA and Lebrun I*
Background: Autism Spectrum Disorder (ASD) is characterized by conditions involving areas of social interaction,
communication and behavior, as well as sensory sensitivity. Studies have reported an association of ASD with alterations
in protein and amino acid metabolism. The aim of this study was to identify the profile of proteins and
amino acids in the urine of children with ASD.
Methods: Prospective cross-sectional study with case-control design. The cases were male children (n=22) with
ASD, aged 3 to 10 years, and the control group was formed by neuro-typical children (n=22), matched for sex and
age. The determination of the amount and composition of proteins was performed by the Bradford method and
the determination of the amount and composition of amino acids by ultra-efficient liquid chromatography (CLUE).
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