Department of Neuro-Oncology and Neuroscience, University of Delhi, Delhi, India
Research Article
A Randomized Study of Radiation Therapy with or without Temozolomide in Elderly and/or Frail Patients and Newly Diagnosed Glioblastoma (GBM)
Author(s): Subhash Thakur*
Addition of temozolamide to standard radiotherapy has shown survival benefit in patient with age 70 or younger. But there has been so far no robust randomized trial evaluating the efficacy of temozolamide with hypo-fractionated radiotherapy. So we in our centre studied the role of Temozolomide with short course (1 week) hypofractionated Radiotherapy in elderly/frail patients. Aims: To compare Overall Survival (OS) and Progression-Free Survival (PFS) between the two arms. Settings and design: The Study was Randomized trial of hypofractionated radiotherapy (25 Gy in 5 fractions) with temozolomide (arm A, N=35) or without temozolomide (arm B, N=35). This study was conducted at Department of Radiotherapy, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Methods and material: Total 70 patients with newly diagnosed Glioblastoma (post-operative) were enrolled and .. View More»
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