Department of Otorhino-laryngology, North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences, Meghalaya, India
Research Article
The Emerging Potential of Securin Upregulation, Premature Anaphase Separation: Sister Chromatid Exchanges as Intermediate End-points to Monitor Oral and Esophageal Carcinogenesis
Author(s): Anupam Chatterjee*, Chongtham SovachandraSingh, Atanu Banerjee, Nabamita Boruah, PoojaSwargiary, B Nongrum and Suvamoy Chakraborty
Objective: The oral and esophageal squamous cell carcinoma are very common in India and their highest incidence has been reported in north-eastern states. Of the several factors that are implicated for these cancers, the habit of chewing raw Areca Nut (AN) with or without tobacco appears to be highly relevant. These cancers have a poor prognosis when the diagnosis is delayed, but curative treatment is possible if the diagnosis is early. The present objective is to validate the screening of Securin upregulation, the frequency of Precocious Anaphase (PAS) and Sister Chromatid Exchanges (SCEs) in non-target cells like human Peripheral Blood Lymphocytes (PBLs) as early indicative parameters of AN with and without tobacco users.
Design: Peripheral blood was collected from 220 donors of which 124 were noncancerous and 96 were cancerous. All the cy.. View More»
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