Department of Rheumatology, Tehran University of Medical Sciences, Tehran, Iran
Research Article
Evaluation of Oxidant and Anti-Oxidant Activity in Rheumatoid Arthritis Patients and their Effects on Rheumatoid Arthritis Disease Activity
Author(s): Taraneh Dormohammadi Toosi, Abbas Dehghani, Ramin Rezaei, Mohammad Hossein Asgardoon, Hossein Mirmiranpour, Abdolrahman Rostamian, Safieh Movasseghi, Shaghayegh Pezeshki*, Payam Hashemi and Alireza Esteghamati
Background: Rheumatoid Arthritis (RA) is the most common cause of systemic inflammatory arthritis
which causes joint destruction. The pathogenesis of RA is not fully understood, but it seems imbalance
between oxidant and antioxidant process, plays a significant role on it. As a result, suppression of
these mechanisms would be helpful to sub side inflammation and eventually control of the disease
activity. The aim of this study was to evaluate the level of oxidant and antioxidant and their effects on
disease activity in RA patients.
Methods: In the following case-control study, we evaluated the levels of Malondialdehyde (MDA) and
oxidized Low-Density Lipoproteins (ox.LDL) as oxidative factors and Catalase (CAT), Glutathione
Peroxide (GSH-Px) and Superoxide Dismutase (SOD) as antioxidants. Also Tumor Necrosis Factor (TNF)-
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