Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, Lebanon
Research Article
Progression to Fragmentation during Cellular Isolation Improves Clinical Glycemic Outcomes in Patients Undergoing Islet Cell Transplantation
Author(s): Steven M. Hadley Jr, Kerrington D. Smith, Sushela S. Chaidarun, Dawn A. Fischer and Timothy B. Gardner*
Context Islet autotransplantation (IAT) involves a complex islet isolation process in which the explanted pancreas is mechanically and enzymatically digested to separate islet cells from exocrine pancreatic tissue. Islet cells transition during the isolation process from being “embedded” in exocrine pancreatic tissue, to becoming “free” once separated from the exocrine tissue, to eventually becoming “fragmented” with ongoing digestion. However, it is unclear if the relative percentage of “embedded”, “free” or “fragmented” islet cells affects subsequent pancreatic endocrine function. Objective Evaluate the effect of each type of islet cell on endocrine function in patients who underwent IAT. Design Retrospective cohort study. Setting Academic tertiary medical center Patients 33 patients who underwent IAT from 2015-.. View More»
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