Department of Immunology, National Center of Neurology and Psychiatry, Japan
Research Article
Corpus Callosum Area: A Reliable and Feasible Neuroimaging Marker of Cognitive Impairment in Multiple Sclerosis
Author(s): Shun Akaike, Tomoko Okamoto*, Ryoji Kurosawa, Youwei Lin, Wakiro Sato, Takashi Yamamura and Yuji Takahashi
Background: Several magnetic resonance imaging markers of cognitive impairment have been reported in multiple sclerosis. Nonetheless, measurement often requires volumetry, a time consuming technique that has problems with respect to accuracy in the segmentation of brain structures. The corpus callosum area is a marker of cognitive impairment that requires no volumetric technique; however, the usefulness of this marker has not been fully examined. This study aimed to determine whether the normalized corpus callosum area is a feasible and sensitive magnetic resonance imaging marker of cognitive impairment in multiple sclerosis.
Methods and findings: A total of 136 patients with multiple sclerosis who underwent the Montreal cognitive assessment and magnetic resonance imaging examination of the head were retrospectively reviewed. The normalized .. View More»
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