Department of Epidemiology and Health Statistics, Lanzhou University, China
Research Article
Multiplicative and Additive Interactions of Hyperuricemia and Hypertension on the Risk of Chronic Kidney Disease: Evidence from a Prospective Population-Based Cohort Study
Author(s): Zhibin Ma, Xiaobin Hu*, Ping Hu, JunLing Shi, Yajjun Wang, Yingli Tian, Hong Liu, Feng Xu and Mengli Nan
Objective: To investigate the association between hyperuricemia (HUA) and the risk of Chronic Kidney Disease (CKD) in the Jinchang cohort and the interaction between HUA and hypertension on the risk of CKD, in order to provide a scientific basis for the prevention and treatment of CKD.
Methods: Based on the Jinchang cohort, a Cox regression model was applied to investigate the association between HUA and the risk of CKD using the non-HUA population as a reference, and HR values (95% CI) were calculated. According to the baseline age (<45 years, 45 years-64 years, ≥ 65 years), gender (male, female), BMI (<24.0 kg.m-2, 24.0 kg.m−2-27.9 kg.m-2, ≥ 28.0 kg.m-2), smoking (no, yes, quit smoking), alcohol consumption (no, yes, quit drinking, the study population diabetes.. View More»
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