Department of Anesthesiology, Guangdong Medical University, Zhanjiang, China
Research Article
Efficacy and Safety of Remimazolam Tosilate for General Anesthesia Induction and Maintenance in Elderly Patients: A Randomized, Controlled Study
Author(s): Fei Yang, Lideng Guo, Xiawei Lai, Zhijing Zhang, Di Wang, Shanpan Peng and Haihui Xie*
Purpose: To evaluate the efficacy and safety of Remimazolam Tosilate (RT) for general anesthesia in
elderly patients.
Methods: 66 patients aged 60 years to 80 years who were scheduled to undergo surgery were
randomized into three groups: Group A (RT 6 mg/kg/h), group B (RT 12 mg/kg/h), or group C
(propofol 2.0 mg/kg-2.5 mg/kg). Primary efficacy indicators (success rate of anesthesia sedation),
secondary efficacy indicators (BIS value, anesthesia induction time, anesthesia awakening time),
safety efficacy indicators (incidence of anesthetic hypotension; incidence of anesthetic hypoxemia,
etc.) and Adverse Events (AEs) were routinely monitored.
Results: The success rate of anesthesia sedation was 95.45% in the 6 mg/kg/h RT group, and 100% in
the 12 mg/kg/h RT and propofol groups. RT was noninferior t.. View More»
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