Department of Oriental Medicine Biotechnology, Kyung Hee University, Republic of Korea
Research Article
Exosomal AZGP1 as a New Diagnostic Marker Candidate for Pancreatic Cancer
Author(s): Ye-Eun Kim, Ki-Young Kim*, Jin Woo Min, Mi Jung Kim and Hee Cheol Kang
Objective: Pancreatic cancer diagnosis is difficult because it usually doesn’t have symptoms until cancer migration.
So, it was called the ‘King of cancer’. To diagnose pancreatic cancer, commonly CA 19-9 was used, but CA 19-9 has
some problems that make it difficult to use solely to diagnose pancreatic cancer. Therefore, new biomarkers for
prognosis and diagnosis of pancreatic cancer were urgently required.
Design: To find exosomal biomarkers, screening was performed using qRT-PCR with exosomal protein coding 7145
genes. Among the candidates, AZGP1 of cell pellets and exosomes was detected by western blot. To check whether
exosomal AZGP1 affects cancer migration, the transmembrane assay was performed.
Result: The gene expression of AZGP1 is only detected in LNCaP and AsPC-1 among teste.. View More»
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