Caroline House, Faculty of Health Sciences, Ben-Gurion University of the Negev Be'er Sheva, Israel
Mini Review
Gynecologic Malignancies have Tumor-associated Macrophages: A Mini Review
Author(s): Zyan Hadhi* and Asraf Qureshi
In gynecologic malignancies, the intricate tumor microenvironment is a significant modulator of anti-tumor
immune responses. The effectiveness of conventional chemotherapy and cutting-edge immunotherapy
techniques is significantly impacted by how cancer cells interact with the wide range of immune effector cells. We
pay particular attention to the function of macrophages in ovarian, endometrial, and cervical malignancies in this
review. We talk about how macrophages developed and how the stimuli from their microenvironment determine
their polarization status. Tumor-associated macrophages (TAMs) within the tumor niche influence treatment
outcomes by promoting tumor development and mediating immune-suppression. We describe clinical tactics
that specifically target TAMs, such as blocking immunological checkpoints, preventing monocyte recruitment to
the tum.. View More»
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