Department of Biostatistics, Epidemiology, and Research Design (BERD), Southern California Clinical and Translational Science Institute (SC CTSI), University of Southern California (USC), Los Angeles, USA
Research Article
Transcranial Magnetic Stimulation for Schizophrenia: A Meta-Analysis
Author(s): Alexander Chen*, Matthew McCarron, Lauren Schooner, Kaevon Brasfield, Jordyn Chesley, Mark Ashla, Selam Mulugeta, Andrew Tung, Carlos Figueroa, Steven J. Siegel, Melissa L. Wilson and Darrin J. Lee
Background: Schizophrenia is a significant cause of morbidity, and current biologic treatments often fail to achieve
remission. Repeated transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation therapy approved
for major depression. Peer-reviewed literature suggests that rTMS may have efficacy for psychosis as well
as negative and cognitive symptoms; however, holistic data regarding the use of rTMS for schizophrenia remains
unclear.
Objective: We aim to synthesize published data of rTMS efficacy in treating schizophrenia and evaluate the most
efficacious treatment parameters.
Methods: A meta-analysis was performed evaluating mean weighted effect sizes (Cohen’s d) and heterogeneity
(Cochran’s I2).
Results: 24 studies were included for analysis (N=.. View More»
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